1st International Workshop on Musculoskeletal Interactions
Santorini 23, 24, 25 & 26 May 1999

Scientific Program


  pQCT User Meeting     Saturday, May 22
     
MORNING: Moderator: G Tysarczyk-Niemeyer
08.30 - 13.00   General Overview
08.30 - 10.30   G Tysarczyk-Niemeyer (Stratec)
Introduction to X-ray Physics
General Concept of pQCT Data Taking
Data Processing
Evaluation of collected data scans
10.30 - 11.00   Break
11.00 - 12.30   J Willnecker (Stratec)
Applications
Animal models
Positioning
Site Selection
Measurement Masks
Loop Project files
Analysis Algorithms
Results Presentation
Clinical Applications
12.30 - 13.00   Open questions
13.00 - 15.00   Lunch (on your own), individual appointments.
     
AFTERNOON: Moderator: J. Willnecker
15.00 - 17.00   User experience (15 min talk, 10 min discussion)
15.00 - 15.25   R Muhlbauer Food fractionation is a powerful tool to increase bone mass in growing rats and to decrease bone loss in aged rats. Modulation of the effect by dietary phosphate.
15.25 - 15.50   SL Cheng Bone properties in relation to muscle strength in early postmenopausal women.
15.50 - 16.15   J Nijs Bone measurements in patients with the benign hypermobility syndrome.
16.15 - 16.40   H Schiessl Comparison of bone and muscle parameters in men and women.
16.40 - 17.00   Conclusions
17.00 - 19.00   Training
19.00   Cocktails

  Day 1     Sunday, May 23
     
pQCT Meeting (2nd Day)
     
MORNING: Moderator: G. Tysarczyk-Niemeyer
10.00 - 10.25   E Schoenau Bone density measurements in children at different skeletal sites.
10.25 - 10.50   L Moyer-Mileur Diet, physical activity, and pubertal status: Relationship to distal tibia bone mineralization in pre-adolescent and adolescent girls.
10.50 - 11.15   Gr Skarantavos Relation of bone and muscle cross section in osteoporosis. Comparison with histology.
11.15 - 11.40   J Willnecker Bone, muscle, and fat measurements with pQCT.
11.40 - 12.00   Conclusions
12.00   Individual appointments.
     
1st International Workshop on Musculoskeletal Interactions
     
Instructional Course: Principles and Terminology in Bone Physiology and Mechanics of the Musculoskeletal System
     
    Moderator: J Gasser
18.00 - 18.30   WSS Jee The biologic determinants of bone mass and strength: growth, modelling, remodelling and repair
18.30 - 18.40   Discussion
18.40 - 19.10   H Schiessl Definitions and units in mechanics.
19.10 - 19.20   Discussion
19.20 - 19.50   M Schaffler Principles in musculoskeletal mechanics.
19.50 - 20.00   Discussion
20.00 - 21.00   Meeting of the International Society of Musculoskeletal and Neuronal Interactions
21.00 - 22.00   Welcome reception
     

1 Day 2     Monday, May 24
     
Session 1:   Adaptation of the skeleton to mechanical stimuli
     
    Moderator: GP Lyritis
08.00 - 08.20   HM Frost Osteoporosis at a crossroads in 1999
08.20 - 08.40   WSS Jee The Utah paradigm of bone physiology.
08.40 - 09.00   Discussion
09.00 - 09.20   E Schoenau Bone and muscle adaptation to growth and usage.
09.20 - 09.40   JL Ferretti, R Capozza, G Cointry, R Capiglioni, E Rodan, JR Zanchetta. Musculoskeletal interactions in humans as revealed by DEXA, QCT and pQCT.
09.40 - 10.00   Discussion
10.00 - 10.30   Coffee break
     
     
Session 2:   Defining and treating Osteopenias and Osteoporoses. Theoretical and practical aspects
     
    Moderator: J Ferretti
10.30 - 10.50   HM Frost Osteopenias and Osteoporoses : What are we measuring, what are we treating?
10.50 - 11.10   D Felsenberg Non-invasive diagnosis of osteopenia and osteoporosis
11.10 - 11.30   Y Jiang, J Zhao, DL White, HK Genant. Non-invasive/non-destructive imaging of trabecular microstructure in osteoporotic animal models.
11.30 - 11.50   S Adami A clinical approach to diagnosis and treatment of osteoporosis
11.50 - 12.10   D Thompson Antiresorptive drugs for the treatment of osteoporosis
12.10 - 12.30   S Wimalawansa Physiology and pharmacology of prevention of Musculo-skeletal losses in simulated microgravity
12.30 - 14.00   Panel discussion on definition and treatment of osteoporoses (S Adami, D Felsenberg, JL Ferretti, M Frost, WSS Jee, D Tompson, S Wimalawansa)
14.00 - 20.00   Free time
20.00 - 22.00   Excursion to Oia (Famous for the sunset in the Aegean Sea).

  Day 3     Tuesday, May 25
     
Session 3:   How bone cells respond to the mechanical stimuli?
     
    Moderator: M Schaffler
08.00 - 08.20   G Marotti The osteocyte as a wiring transmission system
08.20 - 08.40   T Skerry Signalling pathways activated during functional adaptation of the skeleton to mechanical loading suggest a role for excitatory amino acid glutamate.
08.40 - 09.00   Discussion
09.00 - 09.20   Lis Mosekilde Trabecular bone structure and strength. Remodeling and repair
09.20 - 09.40   DN Kalu, JM Banu, L Wang How cancellous and cortical bones adapt to loading and growth hormone.
09.40 - 10.00   Discussion
10.00 - 10.30   Coffee break
     
     
Session 4:   Clinical aspects on calcitonin, bisphosphonates and SERMs actions. The fracture incidence studies
     
    Moderator: S Adami
10.30 - 10.50   D Agnusdei Raloxifene. The MORE Study
10.50 - 11.00   M Azria The role of calcitonin in the management of osteoporosis in day-to-day practice.
11.00 - 11.10   A Gimona, K Adriano, P Richardson Salmon nasal calcitonin spay prevents vertebral fractures in established osteoporosis. Final world-wide results of the PROOF study.
11.10 - 11.30   D Felsenberg Alendronate and fracture prevention.
11.30 - 12.00   Discussion.
12.00 - 13.00   Panel Discussion: What are the long-term effects of antiresorptive drugs on the mechanical properties of bone and on bone quality? (S Adami, D Agnusdei, M Azria, H. Gimona, D Felsenberg).
13.00 - 18.00   Excursion to Akrotiri (A Minoan ancient town of Santorini, which remained intact under the lava and has been recently excavated)
     
     
Session 5:   Interactions of neuromuscular coordination with the function of the musculoskeletal system
     
    Moderator: Gr Skarantavos
18.00 - 18.20   M Runge, G Rehfeld, E Resnicek Balance training and exercise in geriatric patients.
18.20 - 18.40   HW Minne, M Pfeifer, B Begerow Extra-osseous effects of vitamin D supplementation on muscle function, body sway and falling.
18.40 - 19.00   M Peacock Differences in muscle endurance and recovery between fallers and non-fallers, and between young and old women.
19.00 - 19.30   Discussion
19.30 - 20.00   Coffee break
     
     
Session 6:   Oral presentations of selected posters
     
    Moderator: HM Frost
20.00 - 20.15   L Rosenthall, D Bobyn, M Tanzer Periprosthetic hip bone densitometry: Influence of prosthesis design on regional bone remodelling.
20.15 - 20.30   S Tsutsumi, T Sugiura, Y Maeda, M Sogo, Y Inoue Criteria for bone remodeling in computer simulations.
20.30 - 20.45   S Cheng, H Sievanen, A Heinonen, P Kannus Bone properties in relation to muscle strength in early post-menopausal healthy women.
20.45 - 21.00   H Suominen, S Cheng, DR Taaffe, J Puolakka, J Timonen, J Toivanen, JA Toivanen, S Sipila Relationship between bone and muscle mass and strength in post-menopausal women enrolled in exercise and estrogen trials.

  Day 4     Wednesday, May 26
     
Session 7:   Ageing and repair mechanisms
     
    Moderator: G Marotti
08.00 - 08.20   M Schaffler Mechanisms of microdamage repair
08.20 - 08.40   B Noble Osteocyte apoptosis and targeted activity in bone
08.40 - 09.00   Discussion
09.00 - 09.20   DA Lee The effects of mechanical stimuli on articular chondrocytes
09.20 - 09.40   M Koutsilieris Cancer and bone repair mechanisms in osteoblastic metastasis from prostate.
09.40 - 10.00   Discussion
10.00 - 10.30   Coffee Break
     
     
Session 8:   Anabolic Agents and Bone
     
    Moderator: Lis Mosekilde
10.30 - 10.50   WSS Jee Anabolic agents and osteoporosis. Quo vadis?
10.50 - 11.10   D MacLean Effects of growth hormone on bone and muscle
11.10 - 11.30   Discussion
11.30 - 11.50   J Gasser, M Kneissel, JS Thomsen, Li Mosekilde PTH and interactions with bisphosphonates.
11.50 - 12.10   S Adami Applications of PTH in osteoporotic patients
12.10 - 12.30   Discussion
     
     
Session 9:   Physiology of Exercise
     
    Moderator: H Schiessl
12.30 - 12.50   J Rittweger Force and power in phasic and tonic muscle activity.
12.50 - 13.10   M Hartard Effect of exercise in postmenopausal women.
13.10 - 13.30   M Runge, G Rehfeld, J Kupper Rehabilitation of geriatric patients.
13.30 - 14.00   Discussion
14.00 - 18.00   Free time
     
     
Session 10:   Oral presentation of selected posters
(10 minutes presentation followed by 5 minutes of duscussion)
     
    Moderator: WSS Jee
18.00 - 18.15   Gr Skarantavos, A. Michailidis, L. Khaldi, P. Raptou, P. Manavi, Th.Karachalios, E. Chronopoulos, K. Kalogera, G.P. Lyritis. Administration of Small Weekly Methotrexate Doses Has a Temporary Effect on Trabecular Bone in Male Wistar Rats.
18.15 - 18.30   P. Ammann, J.P. Bonjour, R. Rizzoli. Essential Amino Acids Supplements Increase Bone Mass, Bone Strength and Muscle Weight in Osteoporotic Adult Rats.
18.30 - 18.45   EC Firth, N Jopson, CW Rogers. The effects of racetrack exercise on density of New Zealand thoroughbred third metacarpal and carpal bone as determined by computed tomography.
18.45 - 19.00   S. Haering, M Hartard. Long Term Effects of Gallileo 2000 a New Training Device
19.00 - 19.15   Th Karachalios, D Skampardonis, N Roidis, P Manavi, L Khaldi, G. P. Lyritis. The orthotopic placement influences the incorporation and mechanical strength of a loaded structural cortical graft. An experimental study in rabbits.
19.15 - 19.30   D Kaspar, W Seidl, L Claes. In vitro effects of dynamic strain on the proliferative and metabolic activity of human osteoblasts.
     
     
Session 11:   General Discussion (19.30 - 20.30)
   
  • General discussion
  • Proposals and ideas for the 2000s meeting
  • Conclusions
     
21.30 - 24.00   Farewell Dinner

 

  Posters  
1   RC Muhlbauer, F Li Some vegetables (commonly consumed by humans) efficiently modulate bone metabolism.
2   J Kaloudis, Th Karachalios, N Roidis, K Bargiotas, Th Pantazopoulos, M Katsiri, GP Lyritis The effect of a daily administration of 200 IU of nasal calcitonin on biochemical bone markers, bone density and the risk of a contra-lateral hip fracture in patients with a recent intertrochanteric fracture.
3   P Manduca, C Palermo In vitro osteoblasts are induced to increase alkaline phosphatase synthesis and radiolabelled calcium incorporation by an homeopathic preparation.
4   Th Karachalios, L Khaldi, G Lenis, P Raptou, N Roidis, GP Lyritis Calcitonin effects on normal rat bone. A study on the mechanical properties, geometry and mineral density of rat bone.
5   P Manduca, C Filanti, C Palermo, C Sanguineti, A Paddu, A Zicca ECM proteins and metalloproteinases in nodule morphogenesis in tibial rat osteoblast cultures.
6   LJ Moyer-Mileur, TJ McNaught, G Gill, GM Chan Physical activity and diets: Components for improved growth and bone mineralization in premature infants.
7   H Kaessmann, J Holzmannhofer, G Galvan The utility of the score osteoporosis pre-screening instrument
8   Th Karachalios, D Skambardonis, N Roidis, P Manavi, L Khaldi, GP Lyritis The orthotopic placement influences the incorporation and mechanical strength of a loaded structural cortical graft. An experimental study in rabbits.
9   EC Firth, N Jopson, CW Rogers The effects of racetrack exercise on density of new Zealand thoroughbred third metacarpal and carpal bone as determined by computed tomography.
10   HE Bakas, P Ntarlas, N Roussos, K Navalis, G Tzanos Correlation of musculoskeletal pain with working paramaters.
11   G Tzanos, G Tournakis, S Sivetidou, A Papanikolaou, HE Bakas Characteritics of chronic musculoskeletal pain, at the onset and its course.
12   HE Bakas, G Tzanos, G Tournakis, T Loizidis, K Navalis Influence of the chronic musculoskeletal pain on the sexual behavior in correlation with the gender and the diagnosis.
13   T Nakai, K Masuhara, N Kanbara Assessment of bone mineral density in dialyzed patients using dual-energy X-ray absorptiometry.
14   I Binderman, P Einat, R Skaliter, E Feinstein, O Mor, A Faerman Influence of mechanical strain on gene expression patterns in primary rat calvaria cells.
15   P Ammann, JP Bonjour, R Rizoli Essential aminoacids supplements increase bone mass, bone strength and muscle weight in osteoporotic adult rats
16   N Roussos, T Loizidis, K Navalis, S Sapalidou, HE Bakas Exacerbating and alleviating factors in chronic musculoskeletal pain.
17   HE Bakas, N Roussos, S Dimitrakopoulos, S Sivetidou, S Sapalidou, A Nasoufi Does the patient feel responsible for his musculoskeletal pain?
18   A LeBlanc, V Schneider, L Shackelford, S West, V Oganov, A Bakulin, L Veronin Bone mineral and lean tissue loss after long duration spaceflight.
19   JO Cordeladze, J Reseland, CA Drevon Leptin and leptin receptor expression in osteoblasts and osteosarcoma cells.
20   E Ribom, H Brahm, K Piehl-Aulin, H Mallmin, SL Ljunghall Isometric quadriceps muscle strength as a predictor of bone mineral density.
21   HE Bakas, G Tzanos, N Roussos, G Tournakis, T Loizidis, Sivetidou Characteristics of chronic musculoskeletal pain. Questionnaire presentation.
22   N Papaioannou, N Krallis, L Khaldi, G Srakantavos, GP Lyritis The effect of calcitonin on the osteoarthritic (OA) cartilage.
23   C Mitsiades, A Sourla, C Doillon, T Lembessis, M Koutsilieris Three dimensional type I Collagen co-culture system for the study of cell-cell interactions and treatment response in bone metastases.
24   JH Kinney, DL Haupt, NE Lane Three-dimensional morphometry of the L-6 vertebra in the ovariectomized rat model of osteoporosis: Biomechanical implications.
25   L Rosenthall, D Bobyn, M Tanzer Periprosthetic hip bone densitometry: Influence of prosthesis design on regional bone remodelling.
26   JP Devogelaer, G Depresseux Long-lasting effect of pamidronate on bone metabolism in osteoporosis after stopping therapy.
27   S Cheng, H Sievanen, A Heinonen, P Kannus Bone properties in relation to muscle strength in early post-menopausal healthy women.
28   S Tsutsumi, T Sugiura, Y Maeda, M Sogo, Y Inoue Criteria for bone remodeling in computer simulations.
29   CC Liu, DJ Theodorou, SJ Theodorou, MP Andre, DJ Sartoris, SM Szollar, EM Martin, LJ Defots Does spinal osteoporosis occur following spinal cord injury?
30   D Kaspar, W Seidl, L Claes In vitro effects of dynamic strain on the proliferative and metabolic activity of human osteoblasts.
31   A Weiss, A Kaleman, E Bronosar, A Reznick Systemic growth hormone treatment prevents bone loss but not muscle waisting in hindlimbs of aged mice immobilized by denervation.
32   GP Lyritis Effect of calcitonin on pain and post-fracture mobilization.
33   Gr Skarantavos, P Raptou, L Khaldi, A Michailidis, K Rigou, A Gioni, GP Lyritis Osteomalacia: An endogenous bone disease. Relation of bone and muscle cross section in patients suffering from osteomalacia.
34   GV Ioannidis, Gr Skarantovos, P Raptou, L Khaldi, A Galanos, T Karachalios, P Manavi, A Michailides, P Kalogera, GP Lyritis The effect of radial whole body vibration and ERT on the geometric and histomorphometric properties of bone in adult ovariectomized rats.
35   H Suominen, S Cheng, DR Taaffe, J Puolakka, J Timonen, J Toivanen, JA Toivanen, S Sipila Relationship between bone and muscle mass and strength in post-menopausal women enrolled in exercise and estrogen trials.
36   S Haering, M Hartard Long-term effects of Galileo 2000. A new training device.
37   Gr Skarantavos A. Michailidis, L Khaldi, P Raptou, P Manavi, Th Karachalios, E Chronopoulos, K Kalogera, G.P. Lyritis Administration of Small, Weekly Methotrexate Doses Has a Temporary Effect on Trabecular bone in male wistar rats.
38   E.J.A. Roldan, R. Capiglioni, R.F. Capozza, G.R. Cointry, L. J. Ferretti. Postmenopausal changes in the distribution of the volumetric BMD of cortical bone.
39   R. Capiglioni, R.F. Capozza, G.C. Cointry, E.J.A. Roldan, J.L. Ferretti Analysis of the muscle-bone interactions in the human spine by axial QCT.
40   Sunishka M. Wimalawansa, Chandra Yallampalli, David. J. Simmons, Sunil J. Wimalawansa In vitro (osteoblasts) and in vivo (Bone Mineral Density) Dose-Dependent Effects of Nitric Oxide.
41   Sunil J. Wimalawansa An efficacious method of treating postmenopausal osteoporosis: Combined therapy of estrogen and bisphosphonate: 4-year randomized controlled study.
42   Sunishka Wimalawansa, Shankar Vijai, Yang S, Yang J, David J. Simmons, Sunil J. Wimalawansa. The mechanisms of bone resorption by cyclosporin A: Involvement of the Nitric Acid Oxide-eGMP Pathway in Osteoblast-Osteoclast co-cultures.
43   I Koulouris, Gr. Skarantavos, I. Paspati, P. Raptou, G. Trovas, A. Galanos, G.P. Lyritis Changes in geometry and strength of human long bones after 2 years continuous administration of 200 IU intranasal salmon Calcitonin.
44   K. Thorsen, a,c, M. Lundmarka, U. Lernerb and R. Lorentzona In situ microdialysis in human bone tissue: Stimulation of Prastaglandin E2 release by weight-bearing loading but not by muscular exercise
45   K. Thorsen,a,d, P. Nordstroma,b, R. Lorentzona and G. H. Dahlenc Lipoprotein Lp(a), BUT NOT IGF-I, is related to bone mineral density in adolescent mALES
46   A. Itabashi, K. Nemoto, M.Tsuboi, T. Kohno A newly formulated EEL calcitonin Nasal Spray (NDE-1003) has remarkable absorbability and inhibits osteoclastic bone resorption in human

Back to Santorini frame

Last update: 12th of May 1999.